Effects of systemic anti-androgen drugs on the ocular surface Effets des médicaments anti-androgènes systémiques sur la surface oculaıre
Journal Francais d'Ophtalmologie, cilt.45, sa.6, ss.619-627, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 6
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.jfo.2021.06.007
- Dergi Adı: Journal Francais d'Ophtalmologie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.619-627
- Anahtar Kelimeler: Anti-androgen, Ocular surface, Dry eye, Prostate cancer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the effect of systemic anti-androgen drugs on tear function tests and the ocular surface. Methods: Sixty-four male subjects were included in this study. Subjects who were on anti-androgen treatment for prostate cancer (Group A, n: 31) and those who had received only surgical treatment for prostate cancer (Group B, n: 17) were recruited from the department of urology. Age-matched subjects who had never received anti-androgen treatment (Group C, n: 16) constituted the control group. Group A was divided into two subgroups according to the number of anti-androgen drugs used (Group A1: one drug, Group A2: two drugs). All cases underwent a complete ocular examination, including tear film break up time (TBUT), corneal and conjunctival staining, Schirmer 1 test, conjunctival impression cytology, and ocular surface disease index (OSDI) questionnaire. Results: The mean Schirmer's values were 6.87 mm, 11.41 mm, and 13.03 mm in Groups A, B, and C, respectively (P = 0.001). TBUT was 5.45 ± 2.01, 9.85 ± 2.52 and 9.81 ± 1.96 seconds in Groups A, B, and C, respectively (P = 0.001). Schirmer and TBUT were significantly lower, and corneal staining and OSDI questionnaire scores were higher in Group A compared to groups B and C (P < 0.01). Conjunctival impression cytology results according to the Nelson grading system revealed no statistically significant difference between the groups (P = 0.422). Conclusion: Anti-androgen drugs alter tear function tests, cause increased corneal and conjunctival staining scores and worsen complaints of dry eye in patients with prostate cancer.