The effect of the repeated doses of propofol on renal functions of rabbits PROPOFOLUN TEKRARLAYAN DOZLARDA TAVSAN BOBREK FONKSIYONLARINA ETKILERI
Turk Anesteziyoloji ve Reanimasyon, cilt.24, sa.2, ss.59-62, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 2
- Basım Tarihi: 1996
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.59-62
- Anahtar Kelimeler: NAG (N-Acetyl beta glucosaminidase), Propofol, Renal function
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
In this experimental study we aimed to determine the effects of propofol in repeated doses on renal function. 20 male, 3 months old, New Zealand rabbits weighing 2500 ± 750 g were assigned to two equal groups. While 10 rabbits were studied as the control group in the same laboratory conditions; in the other 10 rabbits, propofol was administered at a rate of 50 mg/kg/h following an induction dose of 10 mg/kg. The average duration of infusion was 20 minutes. Giving intervals of 24 hours between the infusion periods the procedure lasted for 20 days. 24 hours after the last infusion period blood and urine samples were obtained to determine blood urea, creatinine, urine creatinine, urine volume, density, creatinine clearance, NAG enzyme levels. Statistical analysis was made by Mann Whitney U test and p<0.05 was considered as significant. No statistical difference was found between the two groups except NAG enzymuria. The NAG enzymuria level in the propofol group was less than the control group. When NAG/creatinine ratios were compared to explain the less enzymuria in the propofol group no statistical difference was found. As a result of our study we conclude that repeated administration of propofol do not causes adverse effects on renal function.