A comparison of magnetic resonance and computed tomography imaging based target-volume definition and interfraction variations of treatment planning parameters (D90 hr-ctv, d2cc for oars) during image guided adaptive brachytherapy for cervical cancer Serviks kanserinde bt ve mr görüntü eşliğinde uygulanan adaptif brakiterapi de hedef volüm tanımı ve dozimetrik parametrelerin (D90 hr-ctv d2cc oar) fraksiyonlar arası değişikliklerinin karşılaştırılması
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, cilt.29, sa.4, ss.227-237, 2019 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.4999/uhod.193962
- Dergi Adı: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.227-237
- Anahtar Kelimeler: Cervical cancer, Image-guided brachytherapy, MRI- guided brachytherapy, CT- guided brachytherapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of this study is to compare computed tomography (CT) and magnetic resonance imaging (MRI) based high-risk clinical target volume (HR-CTV) contours in brachytherapy (BT) for cervical cancer in order to identify patients who may benefit most from MRI-based planning. We also analyzed interfractions variations of the organ at risk (OAR) affects the given doses. Twenty patients who had a pretreatment diagnostic MRI were included. We delineated the HR-CTV and OARs on the CT-and MRI-based scans independently for each patient. Dose-volume parameters D90 HR-CTV and D2cc OARs in CT and MRI plannings were determined and compared; the effect of time on the natural mobility was analyzed. The mean CT and MRI HR-CTV were 28.4 ±11 cm3; 19.0±8.1, (p< 0.001), respectively. The mean EQD2 of CT and MRI HR-CTV were 93.2 ±1.1Gy;92.7±0.6 Gy, (p< 0.041). The mean D2cc of the rectum, bladder, and sigmoid in CT-based plans were higher (17%, 13.3% and 22.8%, respectively) then MRI-based plannings and significant differences were found in patients between the D2cc of rectum (p< 0.001) and sigmoid (p< 0.001). Furthermore, the interfractions volume variations and mean EQD2 doses for all OARs and HR-CTV were statistically insignificant in both image-guided plannings. The use of MRI-based BT for target localization in cervical cancer provides an improved accuracy and precision of the tumor volume as well as a similar dose coverage to the HR-CTV and better minimize the D2cc values of OARs, when it is compared with CT-based planning.