Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia
Endokrynologia Polska, cilt.63, sa.4, ss.260-263, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 4
- Basım Tarihi: 2012
- Dergi Adı: Endokrynologia Polska
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.260-263
- Anahtar Kelimeler: iron overload, endocrine abnormalities, thalassemia major, thalassemia intermedia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Iron overload is a major problem in patients with β-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia. Materials and methods: We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels. Results: According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes. Conclusions: These findings reinforce the importance of regular follow-up of patients with β-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.