The prolonged lowering effect of levosimendan on brain natriuretic peptide levels in patients with decompansated heart failure: Clinical implications
International Journal of Cardiology, cilt.128, sa.1, ss.97-99, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 128 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.ijcard.2008.01.022
- Dergi Adı: International Journal of Cardiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.97-99
- Anahtar Kelimeler: acute heart failure, levosimendan, dobutamine, brain natriuretic peptide, prognosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The release of brain natriuretic peptide (BNP) is increased in heart failure (HF). The plasma concentrations of BNP and N terminal pro-BNP (NT-proBNP) fall after effective pharmacologic treatment of HF, which suggests that measurements of plasma BNP may be helpful in evaluating therapy. Despite the initial reports that suggested a positive effect of levosimendan on short- and long-term survival in patients with severe HF, the results of the recently presented large-scale clinical trials provided rather controversial results. Further clinical studies are needed to end the confusion regarding the effects of levosimendan on prognosis in patients with decompansated HF. © 2008 Elsevier Ireland Ltd. All rights reserved.