Risk factors for cervical stromal involvement in endometrioid-type endometrial cancer

TOPRAK S., Sahin E. A., Sahin H., Tohma Y. A., YILMAZ E., Meydanli M. M.

International Journal of Gynecology and Obstetrics, cilt.153, sa.1, ss.51-55, 2021 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/ijgo.13449
  • Dergi Adı: International Journal of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Public Affairs Index
  • Sayfa Sayıları: ss.51-55
  • Anahtar Kelimeler: cervical stromal involvement, endometrioid-type endometrial cancer, lymphovascular space invasion
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to identify predictors of cervical stromal involvement in women with endometrioid-type endometrial cancer (EEC). Methods: A total of 795 patients with EEC who underwent comprehensive surgical staging including pelvic and para-aortic lymph node dissection between January 2007 and December 2018 were retrospectively analyzed. Data including age, menopausal status, serum CA-125 levels, tumor size, lymphovascular space invasion (LVSI), depth of myometrial invasion, positive peritoneal cytology, cervical stromal involvement, histologic grade, recurrence, and follow-up duration were recorded. Results: Median follow up was 49 months. Cervical stromal invasion was found in 88 patients. Multivariate analysis revealed that presence of LVSI (hazard ratio [HR] 2, 95% confidence interval [CI] 1.02–4.25, P = 0.045), a primary tumor diameter of at least 3 cm (HR 3, 95% CI 1.31–7.25, P = 0.010), and at least 50% deep myometrial invasion (HR 2.7, 95% CI 1.37–5.41, P = 0.004) were independent risk factors for cervical stromal involvement in patients with EEC. Conclusion: Our study results suggest that presence of LVSI, a primary tumor diameter of at least 3 cm, and LVSI of at least 50% seem to be independent predictors of cervical involvement in women with EEC.