Resection of retroperitoneal residual mass after chemotherapy in patients with nonseminomatous testicular cancer
Turkish Journal of Cancer, cilt.31, sa.2, ss.57-62, 2001 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2001
- Dergi Adı: Turkish Journal of Cancer
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.57-62
- Anahtar Kelimeler: Chemotherapy, Lymph node dissection, Testicular cancer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Retroperitoneal lymph node dissection followed by chemotherapy for the treatment of nonseminomatous testis cancer is reserved for partial remissions. One hundred and sixty seven patients with nonseminomatous testis cancer were admitted to Gülhane Military Medical Academy between the years of 1992-1999. Retroperitoneal residual masses determined radiologically were resected in 12 patients (9 teratocarcinoma, 3 embryonal carcinoma) with stage-B after cisplatin-based therapy (PVB in 8 and PEB in 4 patients). Alpha-fetoprotein (AFP) and beta subunit of human chorionic gonadotropin (β-HCG) levels in all patients were normal before resection. The pathologic evaluation of removed retroperitoneal masses showed residual malignancy in 6 patients, mature teratoma in 5 patients and necrosis in 1 patient. Patients with malignant residual tumor (n=6) received chemotherapy, and the others (n=6) were followed by surveillance only. Our data presented herein imply that surgical removal of all post-chemotherapy residual masses is required before suggesting routine salvage chemotherapy.