Choroidal thickness in patients with stargardt disease
Retina, cilt.38, sa.3, ss.614-619, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.1097/iae.0000000000001557
- Dergi Adı: Retina
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.614-619
- Anahtar Kelimeler: central foveal thickness, choroidal thickness, multifocal electroretinography, Stargardt disease, visual acuity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the relationship between choroidal thicknesses (CT), central foveal thicknesses, multifocal electroretinography (mf-ERG) responses, and best-corrected visual acuity levels in patients with Stargardt disease (STGD). Methods: A total of 30 eyes of 30 patients with STGD, and 30 age- and sex-matched healthy controls were included in the study. All participants underwent detailed ophthalmic examination including best-corrected visual acuity and spectral domain optical coherence tomography measurements, and also patients with STGD were performed mf-ERG. Results: The mean subfoveal CT values were 271.95 ± 85.57 mm in patients with STGD and 355.73 ± 87.41 mm in the control group (P, 0.001). The mean central foveal thickness values were 223.56 ± 61.38 mm in patients with STGD and 272.46 ± 27.52 mm in the control group (P, 0.001). The mean central and paracentral mf-ERG responses (45.71 ± 26.60 and 16.47 ± 10.75 Nv/deg2 respectively) in patients with STGD were significantly lower from the normal ranges (66.6–130.8 Nv/deg2 and 30.9–77.7 Nv/deg2, respectively; P, 0.001 for both). There was a statistically significant correlation between subfoveal CT and best-corrected visual acuity levels (P = 0.012, r = 20.452), and between parafoveal CT and inner retinal thickness and paracentral mf-ERG responses (P = 0.043, r = +0.372 and P = 0.049, r = +0.363, respectively). Paracentral mf-ERG responses were also correlated with outer retinal thickness values (P = 0.005, r = +0.503). Conclusion: Patients with STGD have a thinner CT, which may be responsible for some of the clinical findings. The pathophysiological significance of these findings needs further study.