A persistently low HBV DNA level is a predictor of spontaneous HBsAg clearance in patients with chronic hepatitis B
Turkish Journal of Medical Sciences, cilt.46, sa.1, ss.48-52, 2016 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.3906/sag-1411-156
- Dergi Adı: Turkish Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.48-52
- Anahtar Kelimeler: Spontaneous HBsAg seroclearance, incidence, predictor, HBV DNA
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Bckground/aim: The incidence and predictors of spontaneous hepatitis B surface-antigen (HBsAg) seroclearance in patients with chronic hepatitis B virus (HBV) were evaluated. Materials and methods: A total of 1427 patients with chronic HBV infection, who were followed between 1994 and 2013, were investigated in this retrospective study. All data were extracted from patient files. Results: Spontaneous HBsAg seroclearance occurred in 84 patients during 8798 person-years of follow-up. The patients were categorized into 3 groups at follow-up based on HBV DNA features as continuously <100 copies/mL (Group A), 0–10,000 copies/mL (Group B), and 0 to >10,000 copies/mL (Group C). Alanine aminotransferase features in the 2 groups were categorized as continuously normal (<40 U/L) and 0 to >40 U/L. Spontaneous HBsAg seroclearance was seen primarily in patients with Group A HBV DNA features, and continuously low HBV DNA values were the main predictor of HBsAg seroclearance (P < 0.001). Conclusion: These results suggest that a continuously low viral load is the most important factor affecting spontaneous HBsAg seroclearance.