Predicting the Timing of Job Loss and Change in Patients Receiving Standard and Biologic Treatment for Radiographic and Non-Radiographic Axial Spondyloarthritis Vorhersage des Zeitpunkts des Arbeitsplatzverlusts und -wechsels bei Patienten, die eine standard-und biologische Behandlung für radiologische und nicht radiologische axiale Spondyloarthritis erhalten
Aktuelle Rheumatologie, cilt.51, sa.3, ss.173-180, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1055/a-2563-3504
- Dergi Adı: Aktuelle Rheumatologie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
- Sayfa Sayıları: ss.173-180
- Anahtar Kelimeler: non-radiographic axial spondyloarthritis, radiographic axial spondyloarthritis, work capacity evaluation, biological therapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives We focused on investigating clinical and laboratory predictors of the timing of job loss and job changes in non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA (r-axSpA) patients and the effect of biological therapies used. Method The study included 202 axSpA (42 nr- axSpA, 160 r-axSpA) patients who were employed in paid jobs at the time of axSpA treatment initiation. Spinal mobility, disease activity, and functional status were evaluated. During a 5-year follow-up period, patients'occupations, instances of job loss, and occupational changes were documented. Data regarding the timing of job loss and job changes were recorded, including instances of early retirement following job loss. Results r-axSpA patients were diagnosed with notably higher disease activity and required more biologic treatments (p = 0,001, p = 0,001). Job loss and job changes were more prevalent in r-axSpA patients compared to nr-axSpA patients (p = 0,021, p = 0,001). There was no statistically significant association between job loss and biologic therapy type (p = 0,068). High BASMI scores were an independent predictor of job loss (p = 0,040). High BASFI scores and lateral lumbar flexion limitations were significant independent predictors of job change (p = 0,021, p = 0,003). Job loss occurred significantly earlier in patients with a family history of SpA, those who were HLA-B27 positive, and those with cervical limitations, compared to their respective counterparts (p = 0,004, p = 0,050, p = 0,010, respectively). Conclusions r-axSpA patients are particularly vulnerable to these adverse outcomes early in the disease course. Job loss and changes occur more rapidly in patients with HLA-B27 positivity, a family history of the disease, and spinal limitations.