There is no association between premature ovarian insufficiency and levels of fetuin-A/α2-Heremans-Schmid glycoprotein
Journal of Human Reproductive Sciences, cilt.12, sa.4, ss.299-302, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.4103/jhrs.jhrs_104_19
- Dergi Adı: Journal of Human Reproductive Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.299-302
- Anahtar Kelimeler: Fetuin-A, inflammation, premature ovarian insufficiency
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Fetuin-A is a well-known negative acute-phase protein and has been used liberally to predict vascular disease. The aim of this study was to evaluate the association between serum human fetuin-A/alpha2-Heremans-Schmid glycoprotein levels and idiopathic premature ovarian insufficiency (POI). Methods: A total of 75 women were included in this case-control study between January 2013 and December 2013. Serum fetuin-A concentrations were measured in 36 women with idiopathic POI and 39 healthy women with regular cycles. Blood samples were drawn after a 12-h overnight fast and were kept at -80°C for subsequent assay. The serum levels of fetuin-A were assessed by commercial ELISA kits (BioVendor Laboratory Medicine Inc., Brno, Czech Republic) and serum concentration values were expressed as μg/ml. Results: The mean serum fetuin-A levels of idiopathic POI and control women were 229.02 ± 27.79 and 232.37 ± 65.56, respectively, with P = 0.771 (independent samples t-test). Our results showed no statistically significant difference between serum fetuin-A levels of idiopathic POI women and controls. Conclusion: The mean values of serum fetuin-A in idiopathic POI women were not significantly different from controls, which implies that there is no significant association between serum fetuin-A levels and idiopathic POI.