Effect of desloratadine on oxidative and inflammatory ovarian ischemia-reperfusion injury in female rats biochemical and histopathological evaluation
Analytical and Quantitative Cytopathology and Histopathology, cilt.42, sa.2, ss.61-68, 2020 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 2
- Basım Tarihi: 2020
- Dergi Adı: Analytical and Quantitative Cytopathology and Histopathology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.61-68
- Anahtar Kelimeler: Desloratadine, Ischemia, Ischemia-reperfusion injury, Ovarian, Ovary, Rat, Reperfusion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To examine the effect of desloratadine on ovarian ischemia-reperfusion (I/R) injury in rats by biochemical and histopathological methods. STUDY DESIGN: I/R was induced in the right ovaries after distilled water was given to a group of female albino Wistar rats in this study. 15 mg/kg desloratadine was orally administered to another group and I/R was induced in their ovaries, whereas I/R was not induced in the sham operation group. After 2 hours of ischemia and 2 hours of reperfusion, malondialdehyde (MDA), total glutathione (tGSH), nuclear factor-κB (NF-κB), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) levels were measured in ovarian tissues extracted from the body of the animals sacrificed with a high dose of ketamine (120 mg/kg). Tissues were also evaluated histopathologically. RESULTS: It has been revealed that desloratadine significantly inhibited the increase of I/R-associated MDA, NF-κB, IL-1β, and TNF-α levels in the ovarian tissues of animals and the decrease in tGSH levels. In addition, desloratadine decreased severe I/R-associated histopathological damage. CONCLUSION: Our experimental results have shown that desloratadine is beneficial in terms of protecting ovarian tissue against I/R injury.