The effect of albumin and furosemide therapy on hemostatic parameters in nephrotic children
International Pediatrics, cilt.16, sa.4, ss.235-237, 2001 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 4
- Basım Tarihi: 2001
- Dergi Adı: International Pediatrics
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.235-237
- Anahtar Kelimeler: Albumin, Furosemide, Hemostasis, Nephrotic syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
It has been speculated that hyperoncotic salt-poor albumin infusions with furosemide increase the tendency for thrombosis in nephrotic syndrome. In this study, 12 children with minimal change in nephrotic syndrome were treated with 20% salt-poor human albumin and furosemide. They were evaluated before, two-hours and 24-hours after therapy. Lipoprotein (a), protein C and S, factor VIII, von Willebrand factor, prothrombin time (PT), partial thromboplastin time, fibronectin, antithrombin III (AT III), α2 macroglobulin (α2MG), fibrinogen, α1, antitrypsin (α1 AT) ?were measured. The decreases of AT III and α2MG during the second hour, and the decrease of fibrinogen the following day were statistically significant (p<0.05). Fractional excretion of these parameters were statistically insignificant before, two-hours, and 24-hours after albumin and furosemide therapy (p>0.05). In conclusion, a moderate decrease of AT III and <2MG with normalization during the 24th hour were the recorded significant hemostatic parameters.