Acaricidal activities of new potential oxadiazole derivatives on Tetranychus urticae Koch (Prostigmata: Tetranychidae) Yeni potansiyel oksadiazol türevlerinin Tetranychus urticae Koch (Prostigmata: Tetranychidae)'de akarisidal aktiveleri
Plant Protection Bulletin (Turkey), cilt.66, sa.1, ss.96-103, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 66 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.16955/bitkorb.1798659
- Dergi Adı: Plant Protection Bulletin (Turkey)
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.96-103
- Anahtar Kelimeler: acaricide, etoxazole, oxadiazole, Tetranychus urticae
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Tetranychus urticae Koch, 1836 (Prostigmata: Tetranychidae) is a cosmopolitan species known for developing resistance to many pesticides. One strategy to address this challenge is to discover of new groups of active substances. However, the high cost and time required for discovering new molecules have prompted researchers to focus on modifying existing active substances. Etoxazole is an active ingredient reported to be effective against several economically important mite species. Therefore, derivatization studies have been carried out using this compound as a lead structure. In the present study, target molecules containing modifiable oxadiazole groups were designed through a bioisosterism approach, in which the oxazoline ring was replaced with an oxadiazole ring, and substituted phenyl groups were introduced at the C-2 and C-4 positions. When the toxic effects of seven synthesized active substances (3a, 3b, 3c, 3d, 3e, 3f, and 3g) were tested against the nymphal stages of T. urticae, the highest mortality rates were observed for compounds 3b, 3a, and 3g (66%, 64%, and 58%, respectively), following the etoxazole-treated control group. At the egg stage, compound 3a exhibited toxic effects comparable to that of etoxazole, whereas the remaining derivatives displayed relatively lower levels of activity. In conclusion, the findings indicate that derivatives of the oxadiazole group, showing stage-specific activity against T. urticae, represent a promising approach for the development of new control strategies against this pest.