Exchange Transfussion for the Treatment of Severe Indirect Hyperbilirubinemia Caused by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report
Fetal and Pediatric Pathology, cilt.44, sa.6, ss.583-588, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 6
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/15513815.2025.2565690
- Dergi Adı: Fetal and Pediatric Pathology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
- Sayfa Sayıları: ss.583-588
- Anahtar Kelimeler: Exchange transfusion, hyperbilirubinemia, glucose phosphate dehydrogenase, neonate, phototherapy, jaundice
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Hyperbilirubinemia is a common problem during the neonatal period, which can lead to high morbidity and mortality if it is not treated properly. The most common first-line treatment used for hyperbilirubinemia is phototherapy. Glucose-6-phosphate dehydrogenase deficiency (G6PD) can cause indirect hyperbilirubinemia not only with hemolysis but also by affecting bilirubin metabolism in the liver during the neonatal period. In here, we report a three-day-old newborn with severe hyperbilirubinemia who underwent exchange transfusion with a diagnosis of G6PD deficiency to emphasize the importance of keeping in mind erythtocyte enzyme defects in the differential diagnosis of severe indirect hyperbilirubinemia.