Serum intercellular adhesion molecule-1 level in children with sepsis Sepsisli çocuklarda serum interselüler adezyon molekülü-1 düzeyleri
Cocuk Sagligi ve Hastaliklari Dergisi, cilt.46, sa.3, ss.162-168, 2003 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 3
- Basım Tarihi: 2003
- Dergi Adı: Cocuk Sagligi ve Hastaliklari Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.162-168
- Anahtar Kelimeler: Intercellular adhesion molecule-1, Sepsis, Septic shock
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Over the years, diagnosis and treatment of sepsis have undergone significant developments; however, it continues to be an important cause of mortality. Early diagnosis of sepsis reduces mortality and morbidity. Intercellular adhesion molecule-1 (ICAM-1), one of the important immunological markers during the early phases of inflammation, is beginning to be used for early diagnosis of sepsis. In this study the level of ICAM-1 in the blood of 80 children with sepsis was determined by ELISA method and compared with an age-matched group of 20 healthy children. The level of ICAM-1 in children with sepsis was found significantly higher when compared with that of healthy children (p<0.001). In addition, the level of ICAM-1 in children with sepsis who died was statistically significantly higher than that of children with sepsis who survived (p<0.001). In conclusion, ICAM-1 may be a useful marker for diagnosis and for estimating the prognosis of sepsis. It is thought that ICAM-1 may be an early marker for estimating mortality and morbidity.