Intraoperative platelet-rich plasma in tonsillectomy: A randomized controlled trial of pain and wound-healing outcomes
American Journal of Otolaryngology - Head and Neck Medicine and Surgery, cilt.47, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.amjoto.2026.104808
- Dergi Adı: American Journal of Otolaryngology - Head and Neck Medicine and Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: Tonsillectomy, Platelet-rich plasma, Postoperative pain, Wound healing, Postoperative hemorrhage
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To evaluate whether topical autologous platelet-rich plasma (PRP) applied to the tonsillar fossae reduces postoperative pain and improves wound healing after bilateral tonsillectomy. Methods: In this prospective randomized controlled trial with blinded patients and postoperative outcome assessors, 200 patients undergoing bilateral tonsillectomy were randomized 1:1 to receive topical autologous PRP or control treatment. The primary endpoint was postoperative pain trajectory over days 1–10 measured using a visual analog scale (VAS). Secondary endpoints were wound healing, complete mucosal healing by day 14, post tonsillectomy hemorrhage, and postoperative complications. Pain trajectory was analyzed using a repeated-measures mixed effects model. Results: Of 200 randomized patients, 195 contributed evaluable post-baseline data, with no significant baseline differences between groups. In the primary repeated-measures analysis, the PRP group showed lower postoperative pain over days 1–10 than the control group (difference: −0.8 VAS units; 95% CI, −1.2 to −0.4; p = 0.001). Wound healing was significantly better in the PRP group on postoperative days 7, 10, and 14, and complete mucosal healing by day 14 was more frequent with PRP (78% vs 59%; absolute difference 18.8 percentage points, 95% CI 6.0 to 31.6). Secondary hemorrhage rates did not differ significantly between groups (2.0% vs 5.2%; p = 0.28). No serious adverse events occurred. Conclusions: Topical autologous PRP applied during tonsillectomy was associated with reduced postoperative pain and improved wound healing compared with control treatment. PRP may be a useful adjunct for enhancing early recovery after tonsillectomy.