Effects of Nigella Sativa and albendazole alone and in combination in Toxocara Canis infected mice
Journal of the Pakistan Medical Association, cilt.61, sa.9, ss.866-870, 2011 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 9
- Basım Tarihi: 2011
- Dergi Adı: Journal of the Pakistan Medical Association
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.866-870
- Anahtar Kelimeler: Toxocariasis, Mice, Serum liver enzymes, Nigella sativa, Albendazole, Eosinophils
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: Nigella sativa extract has been used in the Middle East as a traditional medicine for several complaints. We aimed to evaluate the biochemical, histopathological and hematologic changes in Toxocara canis-infected mice after treatment with Nigella sativa extract, albendazole or a combination of both. Methods: This comparative study was conducted between June and July 2008 at the Itarran University Saniturla Turkey. Sixty healthy adult BALB/c male mice were randomly divided into six groups (D0-D5). Mice in groups D1- D5 received 500 embryonated T. canis eggs via esophageal tube. Groups D0 and D1 served as a non-infected sham group and an infected control group, respectively. Groups D2 and D3 received 100 and 200 mg/kg N. sativa extract (NSE), respectively. Group D4 received 100 mg/kg albendazole. Group D5 received the combination dose (100+100 mg/kg NSE+albendazole). Results: Treatment with N. sativa of both doses or the combination dose of N. sativa and albendazole reduced the degree of inflammation and necrosis, lead to a reduction in the percentage of eosinophils and decreased the elevated liver enzyme levels. Conclusion: These results indicate that N. sativa has a potent effect in protection against organ damage induced by T. canis infection.