Effects of sodium nitroprusside on ischemia-reperfusion injury
European Journal of General Medicine, cilt.7, sa.1, ss.76-80, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2010
- Dergi Adı: European Journal of General Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.76-80
- Anahtar Kelimeler: Ischemia, Reperfusion, Sodium nitroprusside
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: The aim of this study was to investigate the effects of sodium nitroprussid (SNP) on ischemia-reperfusion injury in rats. Method: Twenty-four Sprague-Dawney rats were divided into four equal groups: group I without ischemia-reperfusion (I-R); group II with ischemia; group III with I-R; group IV with I-R and SNP. Complete bilateral hindlimb ischemia was produced by means of tourniquet occlusion of the upper thigh. Result: Blood creatine phosphokinase, lactate dehydrogenase, aspartate transaminase, urea, creatinine levels were not significantly different between groups 3 and 4. Malondialdehyde (MDA) levels were not significantly different between groups 3 and 4 in liver, soleus muscles and lung tissue. However, MDA levels were significantly lower in group 4 when compared with group 3 in renal tissue. Histological examination of the soleus muscles revealed that neutrophil leukocyte infiltration in group 3 was significantly less prominent than in group 4. Conclusion: These results have shown that SNP was not able to improve muscle ischemia-reperfusion injury in our study.