Analysis of the impact of IMDC score parameters on patients with metastatic clear cell renal cell carcinoma
Biomarkers in Medicine, cilt.19, sa.21, ss.1075-1083, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 21
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/17520363.2025.2589382
- Dergi Adı: Biomarkers in Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1075-1083
- Anahtar Kelimeler: IMDC score, metastatic renal cell carcinoma, survival, predictive significance, parameters
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Although the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) scoring system has been used in metastatic renal cell carcinoma (mRCC) for years, debate continues over its ability to predict survival. Materials and methods: Our study was a single-center retrospective review of medical records of 181 patients diagnosed with mRCC between June 2013 and March 2023. Results: Low serum albumin level (p < 0.001) and high serum uric acid level (p < 0.001) were significantly associated with worse OS. Furthermore, the number of metastatic sites (p = 0.003) had a significantly adverse impact on OS. Although the HGB level of <12 g/dL adversely affected OS (p = 0.042), none of the remaining parameters used for the IMDC scoring had a significant impact on OS. Discussion: Even though the IMDC system scores them equally, we concluded that each parameter might express dissimilarities on survival; some might even lack any significant effect. Furthermore, factors such as serum albumin and uric acid levels, the presence of specific organ metastases, or the number of metastatic sites might affect survival more than the IMDC parameters. Further studies are needed to predict prognosis and develop a treatment plan using an individualized risk score that includes molecular biomarkers, imaging findings, and patient clinical characteristics.