Histomorphometric analysis of new bone obtained by osteogenic periosteal distraction in ovariectomized rabbits
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, cilt.113, sa.4, ss.472-479, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 113 Sayı: 4
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.tripleo.2011.04.012
- Dergi Adı: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.472-479
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective. The aim of this study was to evaluate the effects of estrogen deficiency on newly formed bone obtained by osteogenic periosteal distraction histomorphometrically. Study Design. Thirty-six female rabbits were divided into 2 groups. The experimental group underwent a bilateral ovariectomy and a sham operation was applied to the control group to equalize the stress of ovariectomy surgery. Four weeks postoperatively, a gradual distraction of the mandibular corpus was performed. Results. In the experimental group, callus formation was delayed and the new bone was less mineralized; conversely, when histomorphometric measurements were compared statistically, there were no significant differences between the ovariectomized and sham-operated subgroups in the mean extent of newly formed bone tissue. Conclusions. Although osteoporosis caused by the lack of estrogen has negative effects on osteogenic periosteal distraction (OPD), these negative effects do not appear to present a contraindication to OPD. © 2012 Elsevier Inc. All rights reserved.