Baseline Serum Uric Acid Can Be a Guide for Predicting Acute Kidney Injury in Sepsis Bazal Ürik Asid Düzeyi, Sepsiste Akut Böbrek Hasarının Önceden Belirlenmesi İçin Bir Kılavuz Olabilir
Genel Tip Dergisi, cilt.31, sa.4, ss.391-395, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.54005/geneltip.970853
- Dergi Adı: Genel Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.391-395
- Anahtar Kelimeler: Acute kidney injury, Sepsis, Uric acid
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Sepsis is the most important cause of acute kidney injury (AKI) in the intensive care unit (ICU) with 15%–20% of patients with sepsis-associated AKI prescribed renal replacement therapy. Uric acid has been linked to hypertension, dyslipidemia, fatty liver, renal disease, and cardiovascular disease. Uric acid levels are associated with an increased risk of AKI. Here, we explored whether elevated uric acid levels have a role in predicting AKI in sepsis. Material and Method: This retrospective study enrolled 105 consecutive cases with sepsis admitted to the ICU in this retrospective study between September 2015 and December 2017. Clinical laboratory tests, and a new Simplified Acute Physiology Score (SAPSII) score were recorded on admission; renal function was monitored for seven consecutive days. Results: The rate of AKI 7 days after enrollment was 47.6%. Baseline uric acid levels were higher in the AKI group (Group 1) than in the non-AKI group (Group 2) (p<0.001). In multivariate logistic regression analysis, AKI was independently associated with serum uric acid, albumin, and SAPSII. Serum uric acid could effectively determine AKI in patients with sepsis at a cut-off point of 6.85 mg/dl including a sensitivity of 72.0% and a specificity of 85.5%. Conclusion: Elevated uric acid levels can help predict AKI in sepsis.