Serum uric acid-creatinine ratio as a marker of chronic kidney disease: a retrospective observational study
Biomarkers in Medicine, cilt.19, sa.20, ss.1019-1026, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 20
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/17520363.2025.2586141
- Dergi Adı: Biomarkers in Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1019-1026
- Anahtar Kelimeler: Alcohol disorders, psychotic disorders/schizophrenia, addictions, antipsychotics, psychosocial interventions
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Serum uric acid (SUA) level has been associated with the progression of chronic kidney disease (CKD), but the role of the SUA/creatinine (SUA/Cre) ratio remains unclear. This study aimed to evaluate whether the SUA/Cre ratio is superior to isolated SUA as a marker for CKD. Methods: A retrospective observational study including 524 participants was conducted to compare SUA and SUA/Cre ratio in groups with and without CKD. Participants were categorized into 3 groups according to CKD stage: no CKD (n = 84), CKD stage 1–2 (n = 124), and CKD stage 3–4 (n = 316). Multivariate and receiver operating characteristic (ROC) analyses were performed to assess the association of SUA and SUA/Cre ratio with the presence of CKD. Results: According to the ROC curve, SUA level showed a stronger correlation than the SUA/Cre ratio (area under the curve [AUC] = 0.768 vs AUC = 0.261; p <.001). Conclusions: Although both the SUA/Cre ratio and SUA level were associated with renal dysfunction, SUA was found to be a better marker of CKD.