Relation Between Telomere and Reactive Oxygen Species in Angiogenesis

Kiliccalan I., Erkovan A., Peker S. C.

Proceedings of the National Academy of Sciences India Section B - Biological Sciences, cilt.92, sa.1, 2022 (Scopus)

Özet

Angiogenesis is the formation of new vessels. Various growth factors such as vascular endothelial growth factor, fibroblast growth factor, angiostatin and thrombostatin play a role in the regulation of this process. Tumor angiogenesis can be given as an example of pathological angiogenesis. Telomeres are the structures responsible for maintaining the chromosome structure. As the cells divide, the telomere structure gets shorter. To prevent this, telomerase enzyme and shelterin complex are present in the cell. TRF2, which is in the structure of the shelterin complex, causes an increase in tumor angiogenesis. TRF2 shows its angiogenic effect by binding to PDGFRß. However, reactive oxygen species also cause angiogenesis in tumor cells. In addition, telomere and telomere-related structures are highly sensitive to reactive oxygen species. Hence, we propose that the increase in TRF2 level in tumor cells compared to normal cells is due to reactive oxygen species in our hypothesis. The decrease in the level of cellular reactive oxygen derivatives can both protect telomere structure and decrease tumor angiogenesis and stop the progression of the tumor. In this way, the progression of tumors to the non-curative stage can be prevented. There is no article in the literature regarding the relationship between reactive oxygen species and TRF2 expression in our hypothesis. Studies on this relationship have an important place in revealing a new pathway in tumor angiogenesis and developing new strategies in tumor treatment.