Role of Volumetric Parameters Derived From Ga-68 PSMA PET-CT in Predicting Treatment Response
Prostate, cilt.86, sa.3, ss.372-376, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 86 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/pros.70094
- Dergi Adı: Prostate
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.372-376
- Anahtar Kelimeler: Ga-68 PSMA, PET/CT, PSMA-TV, TL-PSMA
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We aimed to determine whether TL-PSMA, PSMA-TV, and SUVpeak values measured in prostate adenocarcinoma patients who underwent imaging with Ga-68 PSMA PET/CT for primary staging have a role in predicting treatment response. Materials and Methods: Images of 68 patients who underwent Ga-68 PSMA PET/CT for primary staging between March 25, 2019, and December 3, 2021, were analyzed retrospectively. Volumetric parameter data were obtained through manual delineation using a 40% threshold for the prostate gland, lymph nodes, bone, and visceral organ metastases. Results: TL-PSMA(Bone) measurement differed statistically significantly between the treatment-responsive and unresponsive groups (p = 0.049). In addition, TL-PSMA and PSMA-TV parameters showed statistically significant differences between the treatment-responsive and unresponsive groups (p = 0.02 and p = 0.016). We could not find a significant relationship between other volumetric parameters and treatment response. Conclusion: It has been established that the volumetric parameters derived from Ga-68 PSMA PET/CT imaging conducted for primary staging may play a role in predicting treatment response in patients with prostate adenocarcinoma. However, further studies involving larger patient populations are necessary to clarify this issue.