Effect of low versus high early parenteral nutrition on plasma amino acid profiles in very low birth-weight infants
Journal of Maternal-Fetal and Neonatal Medicine, cilt.25, sa.6, ss.770-776, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 6
- Basım Tarihi: 2012
- Doi Numarası: 10.3109/14767058.2011.589873
- Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.770-776
- Anahtar Kelimeler: amino acid intake, early parenteral nutrition, prematurity, very low birth weight
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To study the efficacy of early high doses parenteral nutrition (PN) versus early low dose with progressive increments PN regimens, we performed a prospective randomized study in very low birth-weight infants. Study design: Forty-one appropriate gestational age preterm infants with birth weights ranging from 7501500g were randomly assigned into two groups. In Group 1, infants started on 3.0g/kg/day amino acids (AA) and 3g/kg/day of 20% lipid; in Group 2, AA and lipid were started on 1g/kg/day, and advanced over 3 days to a maximum 3g/kg/day. Blood samples were obtained for AA concentrations before starting of the PN, and at the 7th and 14th days. Results: The mean (±SD) birth weight was 1335g (240), gestational age was 29.7 weeks (1.7) of the study group. The mean body weight and head circumference was similar in the Group 1 and Group 2 at the 14th postnatal days. There was no difference in the blood levels of triglyceride, blood urea nitrogen, creatinine, ammonia, lactat and bicarbonate in the two groups. There was no significant difference in the concentrations of AA except for arginine and asparagine. On day 14, the mean arginine concentrations were significantly higher and asparagine concentrations were lower in Group 2. Conclusion: Although earlier more aggressive administration of AA and fat is not associated with any significant metabolic abnormalities, growth rates and plasma AA concentrations of the infants were similar to infants who AA and lipid given lower in the first day of life. © 2012 Informa UK, Ltd.