Cyanoacrylate is still an Effective Surgical Strategy for Homeostasis: A Rodent Model of Liver Trauma and Evaluation of Early Wound Healing
Tohoku Journal of Experimental Medicine, cilt.268, sa.1, ss.9-17, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 268 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1620/tjem.2025.j067
- Dergi Adı: Tohoku Journal of Experimental Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.9-17
- Anahtar Kelimeler: fibrosis, hemostasis, liver, trauma, wound healing
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The potential hemostatic effects of cyanoacrylate are well-known, but the histopathological effects on application sites are not clearly established. This study aims to understand the histopathological and biochemical parameters of cyanoacrylate application during the early periods of liver traumas. For this purpose, Wistar albino rats weighing 250-300 g were divided into five groups, and liver lacerations on liver lobes were created in study groups. During the study, hematocrit levels during the pre-operative phase and before sacrification, duration of bleeding, post-operative adhesions of intraabdominal compartments, levels of biochemical markers such as hydroxyproline, collagen, matrix metalloproteinase, and histopathological evaluation of liver regeneration were taken into consideration. Results revealed fibrin sealant and cyanoacrylate managed to achieve better hemostasis compared to mechanical compression and regenerated cellulose. Peritoneal Adhesion Scores of regenerated cellulose and cyanoacrylate were higher compared to mechanical compression and fibrin sealant. Histopathologically, all groups had similar levels of fibrosis, only slightly lesser in the mechanical compression group. Biochemical evaluations showed regenerated cellulose and cyanoacrylate had elevated levels of hydroxyproline, collagen I and III. In conclusion, our study demonstrated that cyanoacrylate was as effective as other tissue sealants in achieving hemostasis, and did not increase fibrosis in the early stages of liver regeneration.