Comparative morphometric analysis of intraepidermal and dermal lymphocytes in early mycosis fungoides and some inflammatory dermatoses
Analytical and Quantitative Cytology and Histology, cilt.29, sa.3, ss.153-158, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 3
- Basım Tarihi: 2007
- Dergi Adı: Analytical and Quantitative Cytology and Histology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.153-158
- Anahtar Kelimeler: morphometric analysis, mycosis fungoides, neoplasm, skin
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Early stage mycosis fungoides (MF) may be indistinguishable from some inflammatory dermatoses (IDs) histopathologically. Various morphologic features of lymphocytes in epidermis and dermis may help to differentiate early-stage MF from other IDs. STUDY DESIGN: We studied 25 cases of early-stage MF and 30 cases of various IDs with prominent exocytosis. The following nuclear variables were measured on dermal and epidermal lymphocytes in MF and IDs (control) groups: nuclear area and perimeter, area convex hull, perimeter convex hull, diameter equivalent circle, minimum feret, maximum feret and form factor. All measurements were done using routinely prepared and hematoxylin-eosin- stained slides. RESULTS: There were statistically significant differences (p < 0.01) for all of the morphometric variables between early-stage MF and IDs. CONCLUSION: Our results revealed that the nuclear contour irregularities of intraepidermal lymphocytes are higher than those of dermal lymphocytes in MF. Their nuclear geometry is also different. Comparison of the nuclear features of intraepidermal with dermal lymphocytes may provide additional support in the diagnosis of early-stage MF. © Science Printers and Publishers, Inc.