Correlation between high-resolution computed tomography, neutrophilic inflammation, air-way obstruction and serum interleukin-8 levels in chronic obstructive pulmonary disease Kronik obstrüktif akciǧer hastalıǧında nötrofilik i̇nflamasyon, hava yolu obstrüksiyonu ve serum i̇nterlökin-8 düzeyleri i̇le yüksek rezolüsyonlu bilgisayarlı tomografi bulguları arasındaki korelasyon
Journal of Clinical and Analytical Medicine, cilt.4, sa.4, 2013 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.4328/jcam.1053
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: COPD, HRCT, IL-8, Induced sputum
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: In this study, the correlation between high-resolution computed tomography (HRCT) and neutrophilic inflammation, air-way obstruction and serum IL-8 levels was examined in subjects with stable COPD. Material and Method: 23 stage I, 15 Stage II and 12 Stage III-IV patients with COPD were included in the study. 10 healthy nonsmoking and 20 smoking participants were additionally included to comprise the control group. Pulmonary function tests, sputum induction and blood collection were performed and HRCT assessed using the visual scoring method. Results: We observed that the forced expiratory volume per second (FEV1) decreased and the total lung score (TLS) increased in smoking groups. An elevated number of neutrophils was observed in parallel with increasing stages of COPD, whilst the number of macrophages decreased in parallel. As the stage of COPD increased, the levels of IL-8 increased. A negative correlation between TLS and FEV1 and the number of neutrophils and FEV1 was observed among all subjects (p<0.001). A positive correlation was determined between the number of neutrophils and TLS, and IL-8 and TLS, whilst a negative correlation was observed between IL-8 and FEV1 (p<0.001). Discussion: When determining the degree and severity of inflammation in COPD, IL-8 analysis of induced sputum and both functional and anatomic assessment and staging assessment of HRCT in the early stage, can be effectively utilised.