The effects of agmatine treatment on cisplatin-inducehepatotoxicity: an experimental rat study
Sao Paulo Medical Journal, cilt.144, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 144 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/1516-3180.2025.3392.02032026
- Dergi Adı: Sao Paulo Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Anahtar Kelimeler: Agmatine, Cisplatin, Chemical and drug-induced liver injury, Oxidative stress, Rats
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Cisplatin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent hepatotoxicity, primarily driven by oxidative stress and inflammation. Agmatine, an endogenous polyamine, has demonstrated antioxidant and anti-inflammatory properties in various models; however, its hepatoprotective effects in cisplatin-induced liver injury remain underexplored. METHODS: This experimental study investigated the protective effects of agmatine against cisplatin-in-duced hepatotoxicity in 28 male Sprague Dawley rats. The animals were randomized into four groups: Sham, Cisplatin, Cisplatin + Agmatine (20 g/kg/day, orally), and Placebo. Biochemical markers, including ALT, AST, MDA (malondialdehyde), SOD (superoxide dismutase), GPx (glutathione peroxidase), TNF-α, IL-1β, and TGF-β, were assessed using ELISA (enzyme-linked immunosorbent assay). Histopathological evaluation was performed to assess liver architecture and injury severity. RESULTS: Cisplatin administration significantly increased serum levels of ALT, AST, MDA, and proin-flammatory cytokines (IL-1β, TNF-α, and TGF-β), while reducing antioxidant enzyme activities (SOD and GPx) (p < 0.01). Agmatine co-administration significantly reversed these biochemical alterations and ameliorated histopathological damage, as evidenced by reduced inflammatory infiltration, sinusoidal dilatation, and hepatocellular degeneration. CONCLUSION: Agmatine demonstrates significant hepatoprotective effects against cisplatin-induced liver injury by attenuating oxidative stress and inflammatory responses. These findings suggest its potential role as an adjunctive agent to improve the hepatic safety profile of cisplatin chemotherapy.