Evaluation of electrophysiological changes before and after pramipexole treatment in patients diagnosed with idiopathic restless legs syndrome Pramipexolkezelés előtti és utáni elektrofiziológiai változások értékelése idiopathiás nyugtalan láb szindrómával diagnosztizált betegek körében
Ideggyogyaszati Szemle, cilt.78, sa.1-2, ss.37-46, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 1-2
- Basım Tarihi: 2025
- Doi Numarası: 10.18071/isz.78.0037
- Dergi Adı: Ideggyogyaszati Szemle
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.37-46
- Anahtar Kelimeler: Restless legs syndrome, electro physiological tests, pramipexole
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and purpose – Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, frequently accompanied by unpleasant sensations. In this study, we aimed to determine the changes in electrophysiological tests including F-wave responses and H-reflex parameters in patients with idiopathic RLS after pramipexole medication. Methods –This prospective study was conducted with twenty newly diagnosed, idiopathic RLS patients. The electrophysiological parameters, specifically F-wave duration (FWD), the duration of related compound muscle action potential (CMAPD), and FWD/ CMAPD ratio, the ratio of maximum H-reflex amplitude(H) to maximum M-response amplitude (M)(H/M) were recorded in patients with idiopathic RLS before and after pramipexole medication. Results – The results revealed significant improvements in specific electrophysiological parameters after pramipexole use. We observed a significant decrease in FWD, CMAPD, and FWD/CMAPD values after pramipexole treatment suggesting a reduction in motor neuron excitability. We also observed a significant decrease in H/M ratio after pramipexole medication indicating reduced spinal motor neuron excitability. Conclusion – This study demonstrated significant improvement in specific electrophysiological parameters following pramipexole treatment in patients with idiopathic RLS. The findings provide better understanding of the effects of pramipexole on nerve function and may contribute to the development of a monitoring tool and lead to more targeted treatments and interventions for RLS, improving the overall management and care for patients’ outcomes and quality of life with this debilitating condition.