Procalcitonin: A marker of heart failure
Acta Cardiologica, cilt.70, sa.4, ss.473-478, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 4
- Basım Tarihi: 2015
- Doi Numarası: 10.2143/ac.70.4.3096896
- Dergi Adı: Acta Cardiologica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.473-478
- Anahtar Kelimeler: Biomarker, Heart decompensation, Heart failure, Procalcitonin, Sensitivity and specificity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective Serum procalcitonin levels are associated with congestive heart failure, but are not established biomarkers of the disease. We evaluated the predictive value of serum procalcitonin levels for diagnosing heart failure and assessing its severity. Methods and results This retrospective, case-control study involved 59 subjects (mean age 59.7 ± 10.1 years; 38 males), including 21 outpatients and 19 inpatients with heart failure and left ventricular ejection fractions < 45%, and 19 healthy controls. Serum procalcitonin levels were measured and compared among the 3 groups. Procalcitonin levels were significantly higher among inpatients (median [interquartile range], 1.45 [0.25–5.80] ng/mL) than among the outpatients (0.35 [0.001–1.70] ng/mL; P < 0.001) or controls (0.05 [0.02–0.08] ng/mL; P < 0.001). Using a procalcitonin cut-ofilevel of 0.09 ng/mL, 35 (87.5%) of the 40 inpatients and outpatients were procalcitonin-positive; all control individuals were procalcitonin-negative. Serum procalcitonin levels difierentiated between heart failure patients and healthy controls (sensitivity, 88.9% [95% confidence interval, 75.9–96.2%]; specificity, 100% [82.2–100.0%]; positive predictive value, 100% [91.1–100.0%]; negative predictive value, 79.2% [57.8–92.8%]). Procalcitonin levels were > 0.53 ng/mL in 4/21 (19%) outpatients and in 16/19 (84.2%) inpatients. The sensitivity and specificity of serum procalcitonin levels for difierentiating between inpatients and outpatients were 84.2% and 81.0%, respectively (positive predictive value 80% [95% confidence interval, 67.6–92.4%] and 85.0% [73.9–96.1%], respectively). Conclusion Serum procalcitonin levels, showing high sensitivity and specificity for diagnosing and assessing the severity of heart failure in this small study, might be considered potential heart failure biomarkers.