Comparison of the 68Ga-FAPI Versus 18F-FDG in Gastric Adenocarcinoma and Anthracosis-Associated Lymph Nodes: FAPI Unmasking False-Negatives and False-Positives


Babacan G. B., ÖNER TAMAM M., Şengiz Erhan S., Şahin M. C., Acar Tayyar M. N.

Clinical Nuclear Medicine, cilt.49, sa.3, 2024 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1097/rlu.0000000000005026
  • Dergi Adı: Clinical Nuclear Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Ga-68-FAPI, F-18-FDG, anthracosis, gastric adenocarcinoma, lymph nodes
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

A 73-year-old woman with poorly differentiated gastric adenocarcinoma was referred to 18F-FDG PET/CT for evaluation of the disease. FDG PET/CT showed intense uptake in the disseminated lymph nodes. However, there was no uptake in the primary tumoral lesion. Subsequently, 68Ga-FAPI-04 PET/CT was performed with the decision of the tumor board and demonstrated intense uptake in the tumoral lesion. However, there was low or no uptake in disseminated lymph nodes. Tru-cut biopsy results revealed that all the lymph nodes were associated with anthracosis.