Effects of fibrin glue, 2-octyl cyanoacrylate, and n-butyl cyanoacrylate on cartilage healing: An experimental animal study
Haseki Tip Bulteni, cilt.59, sa.4, ss.268-272, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/haseki.galenos.2021.6915
- Dergi Adı: Haseki Tip Bulteni
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.268-272
- Anahtar Kelimeler: Cartilage, fibrin tissue adhesive, octyl 2-cyanoacrylate, cyanoacrylates
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Following septoplasty surgery, nasal packing is performed to stabilize the healing of septum and prevent septal hematoma. The purpose of this study was to investigate the efficacy of fibrin glue, 2-octyl cyanoacrylate, and n-butyl cyanoacrylate on the healing of the septum cartilage following septoplasty. Methods: Since rabbit ear cartilages resemble septal cartilage, 10 New Zealand rabbits were used in our study which was performed between March and May 2016. A total of 20 ears of 10 rabbits were used, with 4 separate incisions in each ear. Perichondrial flaps were raised and the following chemical adhesives were applied separately on the cartilage: Fibrin glue, 2-octyl cyanoacrylate, n-butyl cyanoacrylate. As the control group, no material was applied to the remaining incision. The right ears were examined at 15 days and the left ears at 30 days; samples were removed with solid tissue around the edges, treated with formol and histopathologically examined. Results: Epithelial integrity and re-epithelialization were adequate in all groups. As the epithelium and perichondrium thicknesses were compared in the 15-day samples, epithelium and perichondrium were thicker in the n-butyl cyanoacrylate and 2-octyl cyanoacrylate groups than the other groups. Conclusion: N-butyl cyanoacrylate, fibrin glue and 2-octyl cyanoacrylate are potential alternatives for cartilage and mucosal support.