Role of augmenter of liver regeneration on testicular ischemia and ischemia/reperfusion injury: An experimental study
Nigerian Journal of Clinical Practice, cilt.26, sa.7, ss.963-972, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 7
- Basım Tarihi: 2023
- Doi Numarası: 10.4103/njcp.njcp_700_22
- Dergi Adı: Nigerian Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
- Sayfa Sayıları: ss.963-972
- Anahtar Kelimeler: Augmenter of liver regeneration, ischemia-reperfusion injury, testicular torsion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Testicular torsion causes ischemic injury, and torsion causes reperfusion injury. Aim: Evaluating the role of augmenter of liver regeneration (ALR) in testicular ischemia and ischemia/reperfusion injury. Materials and Method(s): Seventy-eight (78) healthy Wistar albino male rats were randomly divided into four groups; control (C) (n = 6), sham (S) (n = 24), torsion (T) (n = 24), and torsion/detorsion (T/D) (n = 24). S, T, and T/D groups were divided into four subgroups (n = 6) as 1 st, 2 nd, 3 rd, and 4 th hours. Blood, tissue ALR, and histology analyses were performed between groups and subgroups. Results: The increase in plasma ALR values at the 3 rd and 4 th hours compared to the 1 st hour in the T group were significant (P < 0.01, P < 0.001, respectively). In the T/D group, a significant increase was observed in plasma ALR values at the 3 rd and 4 th hours compared to the 1 st hour (P < 0.05, P < 0.001, respectively). Plasma ALR values at the 1 st, 2 nd, 3 rd, and 4 th hours were higher in the T and T/D groups than in the C group (P < 0.001, P < 0.05, respectively). Plasma ALR values were higher in the T group at the 1 st, 2 nd, 3 rd, and 4 th hours than in the S group (P < 0.05). A significant increase was observed in tissue ALR at the 3 rd and 4 th hours than at the 1 st hour in the T group (P < 0.05, P < 0.001, respectively). A significant increase was observed in tissue ALR at the 3 rd and 4 th hours than in the 1 st hour in the T/D group (P < 0.05, P < 0.001, respectively). Discussion: ALR in plasma and testicular tissue has a potential role in the early diagnosis of testicular torsion and in predicting the prognosis of T and T/D.