The prevalence and outcomes of inflammatory bowel disease among patients with cytomegalovirus disease

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KARACAER Z., BULUT C., Fidan G., Çelebi G.

Gulhane Medical Journal, cilt.67, sa.2, ss.72-76, 2025 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.4274/gulhane.galenos.2024.59251
  • Dergi Adı: Gulhane Medical Journal
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.72-76
  • Anahtar Kelimeler: cytomegalovirus, diagnosis, Inflammatory bowel disease, prognosis, treatment
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Aims: Cytomegalovirus (CMV) colitis in individuals with inflammatory bowel disease (IBD) is a serious condition. The present study evaluated the prevalence and outcome of IBD-CMV colitis among patients with CMV disease. Methods: We performed a retrospective study to evaluate the patients with IBD and CMV colitis between January 1, 2017, and December 31, 2022. We identified IBD-CMV colitis based on the presence of CMV in tissue or a polymerase chain reaction (PCR) result of ≥1000 copies/mL with no other clinical explanations. The frequency of IBD-CMV colitis, relapse rate, requirement of surgical interventions, and associated mortality were assessed. Results: Out of 163 patients with CMV disease screened, 28 (17.2%) were diagnosed with CMV colitis and IBD [median age: 54 (19–67) years, male: 77%]. The frequency of ulcerative colitis and Crohn’s disease was 93% and 7%, respectively. Most CMV PCR assays (97%) were performed using serum, whereas the remaining tests were performed using serum and tissue samples. CMV was not detected via immunohistochemistry or hematoxylin-eosin staining in any patient. Antiviral treatment was initiated in 74% of the patients and lasted a median of 20 days (6–32 days). No surgical interventions or disease-related deaths were identified. Conclusions: This electronic medical records study showed that IBD-CMV colitis was a rare disease among patients with CMV disease and generally followed a favorable course.