Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury
Acta Anaesthesiologica Scandinavica, cilt.53, sa.8, ss.1068-1072, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 8
- Basım Tarihi: 2009
- Doi Numarası: 10.1111/j.1399-6576.2009.02019.x
- Dergi Adı: Acta Anaesthesiologica Scandinavica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1068-1072
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Background: The aim of this study was to compare the anti-inflammatory response of methylprednisolone and the α2-agonist dexmedetomidine in spinal cord injury (SCI). Methods: Twenty-four male adult Wistar albino rats, weight 200-250 g, were included in the study. The rats were divided into four groups as follows: the control group (n: 6) received only laminectomy; the SCI group (n: 6) with trauma alone; the SCI+methylprednisolone group (n: 6) with trauma and 30 mg/kg methylprednisolone, followed by a maintenance dose of 5.4 mg/kg/h; and the SCI+dexmedetomidine group (n: 6) with trauma and 10 μg/kg dexmedetomidine treatment intraperitoneally. Twenty-four hours after the trauma, spinal cord samples were taken for histopathological examination and serum samples were collected for interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α measurement. Results: TNF-α (P=0.009) and IL-6 (P=0.009) levels were significantly increased in the SCI group. TNF-α and IL-6 levels were significantly decreased with methylprednisolone (P=0.002, 0.002) and dexmedetomidine (P=0.002, 0.009) treatment, respectively. Methylprednisolone and dexmedetomidine treatment reduced neutrophils' infiltration in SCI. Conclusions: The current study does not clarify the definitive mechanism by which dexmedetomidine decreases inflammatory cytokines but it is the first study to report the anti-inflammatory effect of dexmedetomidine in SCI. Further studies are required to elucidate the effects of dexmedetomidine on the inflammatory response. © 2009 The Acta Anaesthesiologica Scandinavica Foundation.