PREPARATION AND IN VIVO EVALUATION OF PIROXICAM SUBGLINGUAL POLYMERIC FILMS PİROKSİKAM DİLALTI POLİMERİK FİLMLERİNİN HAZIRLANMASI VE İN VİVO DEĞERLENDİRİLMESİ
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.48, sa.3, ss.1128-1134, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.33483/jfpau.1514714
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1128-1134
- Anahtar Kelimeler: Film, maltodextrin, pharmacokinetic, piroxicam, pullulan
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Although it is known that different drug applications can increase the effect of drugs, there are many studies that shows the superiority of different dosage forms. The reason of these different results is due to the different properties of used active ingredients. In this study, the potential use of piroxicam sublingual polymeric film application was investigated. Material and Method: In the study, maltodextrin and pullulan sublingual films containing piroxicam were prepared, and plasma levels of the drug were investigated in a healthy rabbit in vivo model. Result and Discussion: In vivo results showed that piroxicam reached its highest plasma concentrations within 10 hours after a single dose administration. Additionally, a second peak corresponding to possible gastrointestinal absorption did not occur in the plasma drug profile. In summary, it has been determined that piroxicam-loaded sublingual polymeric film application can be used to provide an analgesic effect.