Assessment of colchicine adherence and influencing factors in paediatric familial Mediterranean fever

Erdem Torun Ş., ÇELİKEL E., Ekici Tekin Z., Ertem Ş., Özçelik M., Özçelik E., ...Daha Fazla

Scandinavian Journal of Rheumatology, cilt.55, sa.4, ss.289-297, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 4
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/03009742.2026.2618334
  • Dergi Adı: Scandinavian Journal of Rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
  • Sayfa Sayıları: ss.289-297
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: This study evaluated colchicine adherence in children and adolescents with familial Mediterranean fever (FMF) using the Medication Adherence Scale in FMF Patients (MASIF), and examined the influence of patient-related factors and family history. Method: A cross-sectional study was conducted among 324 paediatric FMF patients (1–18 years old). Colchicine adherence was measured via MASIF, and demographic, clinical, genetic, and socioeconomic variables were analysed. Results: Of 324 patients (mean age 11.8 ± 3.8 years), 88 (27.2%) showed good adherence and 236 (72.8%) poor adherence. Adherence was not significantly associated with sex, age group, age at diagnosis, disease severity, family history, colchicine intolerance/resistance, or biologic use. Erysipelas-like erythema was present in 28 patients (8.6%) at diagnosis and correlated with better adherence (p = 0.016). Of the 142 patients (43.8%) who self-reported regular colchicine use, MASIF indicated poor adherence in 101 (71.1%). School absenteeism was reported in 41 (46.6%) of the adherent group and 171 (72.5%) of the non-adherent group (p < 0.001). Conclusion: Colchicine non-adherence is frequent in paediatric FMF and largely unrelated to patient factors. Objective tools such as MASIF reveal higher non-adherence rates than self-reports and are essential for accurate evaluation in clinical decision making.