Morphological changes of the retinal layers in the central macula in children with anisometropic amblyopia Changements morphologiques des couches rétiniennes dans la macula centrale chez les enfants atteints d'amblyopie anisométrope
Journal Francais d'Ophtalmologie, cilt.46, sa.4, ss.363-368, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.1016/j.jfo.2022.10.006
- Dergi Adı: Journal Francais d'Ophtalmologie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.363-368
- Anahtar Kelimeler: Anisometropic amblyopia, Children, Retinal layers, Macula, Optical coherence tomography
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: The goal of this study was to evaluate the morphological characteristics of the retinal layers in the central macula in children with anisometropic amblyopia. Methods: This comparative, observational, prospective study included 28 patients who were diagnosed with anisometropic amblyopia and 30 age- and sex-matched healthy controls. All children were evaluated using the automatic calculation software system available on spectral-domain optical coherence tomography (SD-OCT) for automated segmentation of the macula. Results: Of the included patients, 18 (64.3%) were male and 10 (35.7%) were female, with a mean age of 10.3 ± 3.4 years. Mean spherical equivalent and best-corrected visual acuity (BCVA) were 4.13 ± 1.95 diopters and 0.707 ± 0.36 logMAR, respectively. The mean axial length was significantly lower in amblyopic eyes compared to fellow eyes (22.1 ± 0.34 mm vs. 23.3 ± 0.42 mm, P < 0.0001), and control eyes (22.1 ± 0.34 mm vs. 23.1 ± 0.40 mm, P < 0.0001). The mean thickness of the outer nuclear layer was significantly lower in amblyopic eyes compared to fellow eyes (79.8 ± 11.9 μm vs. 86.8 ± 7.9 μm, P = 0.007), and healthy controls (79.8 ± 11.9 μm vs. 87.4 ± 10.5 μm, P = 0.012). Conclusion: The results of this study showed that there are quantitative differences in retinal microstructures of the macula in eyes with anisometropic amblyopia compared to fellow eyes and healthy controls. These findings suggest that anisometropic amblyopia may result in abnormal development of macular structure in the inner retinal layer. A detailed analysis of retinal layers may be able to provide a guide to the depth of amblyopia and visual prognosis.