Evaluation of platelet indices in young male patients with hepatitis C Hepatit C enfeksiyonu olan genç erkek hastalarda platelet parametrelerinin değerlendirilmesi
Journal of Clinical and Analytical Medicine, cilt.7, sa.5, ss.706-710, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 5
- Basım Tarihi: 2016
- Doi Numarası: 10.4328/jcam.4537
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.706-710
- Anahtar Kelimeler: Hepatitis C Virus, Fibrosis, Platelet Indices, Mean Platelet Volume, Platelet To-Lymphocyte Ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: In light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with hepatitis C virus (HCV) depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and platelet-to-lymphocyte ratio (PLR) in male patients with HCV infection compared with healthy controls. Material and Method: Patients with HCV infection who applied to an Infectious Diseases clinic between 01 January 2012 and 01 June 2015 were evaluated retro-spectively. Overall, 21 male HCV patients who underwent percutaneous liver biopsy and 22 gender-and age- matched healthy controls were included in the study. Statistical analyses were performed by SPSS 15.0. Results: There was no significant difference in age variable between the patients group with an age range of 21-41 years [22 (Iq=4), 24.62±5.84 years] and the con-trol group with an age range of 21-41 years [22,5 (Iq=5), 24.59±5.21 years]. The distribution of fibrosis scores among HCV patients was 23.8% fibrosis score 1, 61.9% fibrosis score 2, and only 14.3% fibrosis score 3. Lymphocyte counts, platelet counts, PLR, platelet volume, distribution width, and platelet-crit values were lower, and mean platelet volume (MPV) values were higher, in the patients group compared with controls, but there was no statistical dif-ference between the two groups. There was also no significant difference in platelet counts, platelet indices, or PLR values between groups according to the fibrosis scores or according to the histological activity index (HAI) score. Discussion: In our study, there were minimally but not significantly affected platelet counts, platelet indices, and PLR values in young adult male patients with minimal or moderate fibrosis induced by HCV infection. However, in pa-tients with advanced liver fibrosis or cirrhosis whose platelet counts may be lower, platelet indices may increase in importance.