Effects of sodium benzoate on the complications of 1.5 glycine solution using two different intravesical pressures during bladder irrigation
Acta Anaesthesiologica Scandinavica, cilt.48, sa.4, ss.438-442, 2004 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1111/j.1399-6576.2004.00349.x
- Dergi Adı: Acta Anaesthesiologica Scandinavica
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.438-442
- Anahtar Kelimeler: glycine, sodium benzoate, transurethral prostate resection, urea cycle
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: In this experimental study we researched the effects of sodium benzoate on the complications of 1.5% glycine solution using with two different intravesical pressures during bladder irrigation. Methods: Thirty-six male adult New Zealand rabbits with body weight ranging from 1500 to 2800 g were used in the experiments. The rabbits were randomly allocated to four groups. In groups 1 and 2, 500 ml of 1.5% gylcine was used as irrigating fluid during 30 min, but only group 2 received 500 mg kg-1 of sodium benzoate treatment by oral route immediately after irrigation. In groups 3 and 4, 500 ml of 1.5% glycine was used as irrigating fluid during 60 min, but only group 4 received the same treatment as group 2. Ammonia, urea, sodium, potassium, hemoglobin, hemotocrit and platelet levels were studied at preirrigation and postirrigation on the 4 h and 24 h. Also electrocardiographic (ECG) changes were monitored at the same time with blood parameters. Results: At 4 h postirrigation, Na+ levels were decreased significantly in group 1 and non-significantly in group 3 when compared with preirrigation levels. But these levels were not changed in groups 2 and 4. Both at 4 h and 24 h, ammonia and urea levels were significantly increased in groups 1 and 3. Ammonia level was decreased but the urea level was not changed in groups 2 and 4 at the same time points. K+ level was significantly changed only in group 1 at 4 h and 24 h. Hemoglobin and hemotocrit concentrations were decreased both at 4 h and 24 h compared with preirrigation levels in all groups. Also there were ECG changes between the treated and untreated groups. Conclusion: Sodium benzoate was very effective against the complications of 1.5% glycine during bladder irrigation experimentally. But this needs further investigation, especially for the applicability of this new treatment model in human TURP syndrome.