Systemic Coagulation Inflammation Index Associated With Bleeding in Acute Coronary Syndrome
Kardiologiya, cilt.63, sa.10, ss.72-77, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 10
- Basım Tarihi: 2023
- Doi Numarası: 10.18087/cardio.2023.10.n2586
- Dergi Adı: Kardiologiya
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.72-77
- Anahtar Kelimeler: Systemic coagulation inflammation index, acute coronary syndrome, ST segment elevated myocardial infarction, non-ST segment elevated myocardial infarction, bleeding
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim Assessment of the inflammatory component of acute coronary syndrome (ACS) and the degree of activation of the coagulation cascade may provide prognostic information. The systemic coagulation-inflammation index (SCI) assesses both inflammation and the coagulation system, and it has also been found to be associated with clinical outcomes. We investigated the relationship between SCI and in-hospital clinical events (acute kidney injury, cardiogenic shock, life-threatening arrhythmia, bleeding) and mortality. Material and methods The study included 396 patients aged ≥18 yrs who were hospitalized with a diagnosis of ACS. The SCI was calculated using the formula: platelet count (103/µl) X fibrinogen (g/l)/white blood cell (WBC) count (103/µl). Patients were divided into two groups according to whether their SCI score was >100 or <100, and the relationship between clinical and laboratory characteristics was analyzed accordingly. Results The mean age of the patients was 61.4±12.2 years and 78.3% (n=310) were male. The type of ACS was NSTEMI in 56.1% (n=222). The responsible vessel was the left anterior descending artery (LAD) in 42.4% of the patients (n=168). The mean SCI score was 97.5±47.1. WBC, neutrophil, and lymphocyte counts were higher in the SCI <100 group, whereas fibrinogen, C-reactive protein, and platelet count were higher in the SCI >100 group. Bleeding from any cause as an in-hospital complication was significantly higher in patients with SCI >100 (p<0.05). Other in-hospital events were not significantly associated with SCI (p>0.05). Conclusions Bleeding in ACS patients was significantly more common in the group with SCI >100. Thus, SCI may be a useful parameter for predicting in-hospital bleeding complications in ACS. On the other hand, SCI was not associated with mortality and other in-hospital clinical events.