Patients with ANCA-associated vasculitis have low serum thiol levels, and these low levels are correlated with higher disease activity scores ANCA ilişkili vaskülit hastaları düşük serum tiyol düzeylerine sahiptir ve düşük tiyol düzeyleri yüksek hastalık aktive skorları ile ilişkilidir

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Kor A., Akan S., Fırat Oğuz E., Güven S. C., MARAŞ Y., EREL Ö., ...Daha Fazla

Journal of Turkish Society For Rheumatology, cilt.17, sa.2, ss.68-76, 2025 (Scopus, TRDizin)

Özet

Objective: This study compared thiol/disulfide balance and ischemia-modified albumin (IMA) levels between the patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and healthy controls. Additionally, the study investigated the relationship between AAV disease activity scores, organ involvement, and levels of IMA and thiol/disulfide molecules. Methods: Forty-six AAV patients and 45 healthy volunteers were included in the study. Birmingham vasculitis activity score (BVAS) version 3 was used for AAV disease activity. Disulfide (-SS), native thiol (-SH), and total thiol (-SH+-SS) molecule analyses were performed using an automatic spectrophotometric method, and IMA calculations were performed using the albumin-cobalt binding test. An increase in the-SS/(-SH+-SS) ratio was considered indicative of a shift towards oxidation, while an increase in the-SH/(-SH+-SS) ratio was suggested a shift towards antioxidation. Results: The-SS/(-SH+-SS) ratio was significantly higher [β: 0.482, odds ratio (OR) confidence interval (CI) 95%: 0.618 (0.432-0.882), p=0.008] and the-SH/(-SH+-SS) ratio was lower [β:-0.242, OR (CI 95%): 1.273 (1.065-1.522), p=0.008] in the AAV group compared to the control group. A significant association was found between-SH and BVAS-3 [β:-8.202, CI 95%:-16.108-(-0.267), p=0.043]. Conclusion: Thiol/disulfide molecules are shifted towards oxidation in AAV patients compared to healthy controls. Furthermore, patients with higher BVAS-3 disease scores exhibit lower serum thiol levels.