Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-tese: A pilot study

Çelik Ö., Hatırnaz Ş., Erşahin A., Başbuğ A., Yıldırım G. Y., Özener V., ...Daha Fazla

Journal of the Turkish German Gynecology Association, cilt.21, sa.2, ss.70-78, 2020 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/jtgga.galenos.2019.2018.0154
  • Dergi Adı: Journal of the Turkish German Gynecology Association
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.70-78
  • Anahtar Kelimeler: Testis, magnetic resonance spectroscopy, sperm retrieval, micro-TESE, non-obstructive azoospermia
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA). Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previous micro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopy sequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively and compared with the results of the micro-TESEs. Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. A high Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showed a marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value of Cr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm. Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE.