Left frontal lobe N-acetylaspartate levels in patients with deficit schizophrenia Defisit şizofreni olgularinda sol frontal lob N-asetilaspartat Düzeyleri

Özdemir B., UZUN Ö., Özşahin A., Battal S.

Klinik Psikofarmakoloji Bulteni, cilt.15, sa.3, ss.112-118, 2005 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2005
  • Dergi Adı: Klinik Psikofarmakoloji Bulteni
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.112-118
  • Anahtar Kelimeler: Deficit schizophrenia, Left frontal lobe, N-Acetylaspartate, Proton magnetic resonance spectroscopy
  • Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Objective: This study aimed to detect the N-acetylaspartate levels of the left frontal lobe in patients with deficit schizophrenia. Method: Schizophrenia was diagnosed using the DSM-IV criteria. Deficit syndrome was screened by means of the Schedule for the Deficit Syndrome. The subjects were 27 patients with schizophrenic categorized as deficit (N=13) or nondeficit (N=14) and 10 healthy subjects. Severity of illness was measured using the 18-item Brief Psychiatric Rating Scale. Levels of positive and negative symptoms were measured using the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Proton magnetic resonance spectroscopy was performed to measure the levels of metabolite (N-acetylaspartate, creatine, and choline) in left frontal lobe. Results: Level of N-acetylaspartate (NAA) of patients with the deficit syndrome was negatively correlated to the Scale for the Assessment of Negative Symptoms total scores. The patients with the deficit syndrome had significantly lower level of NAA than did the healthy subjects or nondeficit patients. In addition, the patients with the deficit syndrome had significantly lower ratios of choline than did the healthy subjects. Conclusion: As N-Acetylaspartate levels could reflect neuronal density, this finding suggests a neuronal loss in the left frontal lobe (hypofrontality hypothesis) of patients with deficit schizophrenia.