Oncologic outcome in patients with 2018 FIGO stage IB cervical cancer: Is tumor size important?

Tokalioglu A. A., Kilic C., Oktar O., Kilic F., ÇAKIR C., Yuksel D., ...Daha Fazla

Journal of Obstetrics and Gynaecology Research, cilt.49, sa.2, ss.709-716, 2023 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1111/jog.15505
  • Dergi Adı: Journal of Obstetrics and Gynaecology Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, MEDLINE
  • Sayfa Sayıları: ss.709-716
  • Anahtar Kelimeler: 2018 FIGO stage, cervical cancer, prognostic factors, survival
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: To evaluate the prognostic factors and oncologic outcome in patients with 2018 International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer (CC) after radical hysterectomy and lymphadenectomy. Materials and Methods: This study included 290 patients with type II or III radical hysterectomy + pelvic ± para-aortic lymphadenectomy and 2018 FIGO stage IB1-3 epithelial CC. Disease-free survival (DFS) estimates were determinate by using the Kaplan–Meier method. Survival curves were compared using the log-rank test. Multivariate analysis was performed using a Cox proportional hazards models. Results: The mean age of study cohort was 52 ± 10.25 years. Five-year DFS was 93% in entire cohort. On univariate analysis, surgical border involvement (p = 0.007), lymphovascular space invasion (LVSI) (p = 0.040), uterine involvement (p = 0.040), and depth of cervical stromal invasion (p = 0.007) were found to have statistical significance for DFS. However, none of them were independent prognostic factors for the risk of recurrence. Tumor size according to 2018 FIGO staging criteria was not related with recurrence. Conclusions: Surgical border involvement, LVSI, depth of cervical stromal invasion, and uterine involvement were predictors for DFS on univariate analysis. Tumor size was not predicting to recurrence in patient with 2018 FIGO stage IB1-3 CC.