Comparison of the effects of aminoguanidine and l-carnitine treatments on peripheral neural responses in alloxan-diabetic rats
Acta Pharmaceutica Turcica, cilt.40, sa.4, ss.161-168, 1998 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 4
- Basım Tarihi: 1998
- Dergi Adı: Acta Pharmaceutica Turcica
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.161-168
- Anahtar Kelimeler: Alloxan, Aminoguanidine L-carnitine, Aminoguanition velocity, Diabetic neuropathy, Nerve conduction velocity, Rat
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The effects of aminoguanidine (AG) and L-carnitine (LC) on nerve conduction velocity (NCV) and neural levels of malondialdehyde (MDA), a product of lipid peroxidation, were compared in alloxan-diabetic rats. AG and LC were given to diabetic rats starting from the 3rd week after the induction of diabetes and lasting for 4 weeks. NCV was measured in the caudal nerves once weekly during the treatments. Diabetes caused deficits in NCV (p < 0.05 vs non-diabetic control rats). AG and LC improved NCV similarly (p < 0.05 for either treatment vs untreated diabetic rats). Diabetes caused elevation in neural MDA levels (p < 0.05 vs non-diabetic group) which was prevented by both AG and LC (p < 0.05 vs untreated diabetic rats, respectively). Weight and the glucose levels were not influenced by the treatments. Our results suggest that improvements in NCV during 1 month of treatment with AG and LC are comparable in alloxan-diabetic rats. Our results also suggest that the beneficial effects of both AG and LC on diabetic neuropathy are not associated with the regulation of glycemia, but may be related with prevention of lipid peroxidation.