Evaluation of renal tubular function in children taking anti-epileptic treatment
Nephrology, cilt.11, sa.6, ss.485-488, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 6
- Basım Tarihi: 2006
- Doi Numarası: 10.1111/j.1440-1797.2006.00699.x
- Dergi Adı: Nephrology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.485-488
- Anahtar Kelimeler: anti-epileptic, carbamazepine, lamotrigine, N-acetyl-beta-D-glucosaminidase, renal tubular function, valproate
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim: To assess the effects of anti-epileptic drugs on renal tubular function. Methods: Urinary N-acetyl-β-D-glucosaminidase activity was measured in 114 epileptic children (mean age 5.6 ± 1.1 years) who were undergoing monotherapy with valproate (n = 46), carbamazepine (n = 34), lamotrigine (n = 13) and combined therapy with valproate+carbamazepine (n = 21). Results: The urinary N-acetyl-β-D-glucosaminidase index of valproate (P < 0.01), carbamazepine (P < 0.05) and polytherapy group (P < 0.01) were significantly elevated when compared with that of the control group. No significant difference in N-acetyl-β-D-glucosaminidase levels was found between the lamotrigine group and the control subjects. We found that the distribution of the N-acetyl-β-D-glucosaminidase values of patients depended significantly on the length of therapy (P < 0.01). The level of urinary excretion of N-acetyl-β-D-glucosaminidase was significantly higher in the patients who were taking long-term treatment (>10 years) with valproate, carbamazepine and combined therapy than those taking therapy shorter than 10 years (P < 0.01). The mean serum concentrations of valproate and carbamazepine were 68.7 ± 17.44 μg/mL and 5.41 ± 1.23 μg/mL, respectively. There was a significant correlation between the serum concentration of valproate and urinary N-acetyl-β-D-glucosaminidase levels (r = 0.44, P < 0.01). There was also a significant correlation between the serum concentration of carbamazepine and N-acetyl-β-D-glucosaminidase excretion (r = 0.52, P < 0.01). Conclusion: The present study demonstrated that in patients treated with valproate and carbamazepine, an impairment of tubular function can be present, whereas lamotrigine does not cause any significant change. © 2006 The Authors.