Electrophysiological analysis of cortical excitability and inhibition using transcranial magnetic stimulation for understanding aggressive behaviors in antisocial personality disorder Antisosyal kişilik bozukluǧunda saldιrganlιǧιn nedenini anlamaya yönelik olarak kortikal eksitabilite ve inhibisyonun elektrofizyolojik incelenmesi
Noropsikiyatri Arsivi, cilt.46, sa.2, ss.44-48, 2009 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2009
- Dergi Adı: Noropsikiyatri Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.44-48
- Anahtar Kelimeler: Aggression, Antisocial personality disorder, Cortical inhibition, Corticospinal excitability, Transcranial magnetic stimulation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Some biological researches on aggressive behaviors suggest that cortical excitability and inhibition imbalance cause behavioral problems like reactive aggression, impulsivity and inability to behavioral control. The purpose of the study is to evaluate whether cortical excitability-inhibition imbalance is responsible for aggressive behaviors in adult young men with antisocial personality disorder in which aggressive behavior is one of the key features. Method: We studied 42 subjects with antisocial personality disorder and 44 healthy controls matched for age and education level. The electrophysiology of cortical inhibition and excitability was measured with transcranial magnetic stimulation. SCID-I, SCID-II, Aggression Questionnaire, and Edinburg Handedness Inventory were performed to all subjects. Results: Motor threshold, cortical latency, and central motor conduction time, which are related with cortical excitability, have been found statistically significant lower on antisocial personality disorder group compared with healthy controls. There was no difference between two groups on cortical silent period which reflects cortical inhibitory mechanisms. Conclusion: The results indicate an increase in cortical motor excitability on antisocial personality disorder, and we suggest that the cortical imbalance might render the person prone to behavior problems. © Archives of Neuropsychiatry, Published by Galenos Publishing. All rights reserved.